IciStem is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders.
The IciStem consortium is composed of an expert European review panel of hematologists with experience in allogeneic SCT procedures along with infectious disease specialists, virologist and immunologists with expertise in the field of HIV-1 tropism, reservoirs and cure.
We prospectively study allogeneic SCT recipients with HIV-1 infection, collecting complete information on underlying malignancy, chemotherapy, transplant procedure, donor selection, HIV-tropism, cART, and virological and immunological characteristics of a variety of samples before and after the transplant.
IciStem investigates systematically the HIV reservoir in people living with HIV who either had or may get an allogeneic stem cell transplantation. Each patient registered at the IciStem program participates in a local study led by his/her treating physicians. IciStem advises systematic collection of clinical data and blood, tissue and CSF samples before and after the stem cell transplantation. Read more here.