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2019

Arevir Meeting 2019, 3-4 May 2019, Cologne, Germany
Presentation: Potential for HIV Cure by stem cell transplantation (IciStem)
Presenter: Monique Nijhuis
Date: May 4, 2019

IAS Advocacy-for-Cure Academy, 29 April - 1 May 2019, Botswana
Oral presentation: Scalability of HIV Cure – A look at the IciStem consortium
Presenter: Annemarie Wensing
Date: May 1, 2019

Functional Cures and the Eradication of HIV, 24-28 March 2019, Canada 
Poster presentation: Allogeneic stem cell transplantation reduces HIV latent reservoir under cART independently of CCR5-mutated donor
Presenter: Maria Salgado
Date: March 28, 2019

CROI 2019, 4-7 March 2019, Seattle, USA
Poster presentation: Analytic Treatment Interruption (ATI) after Allogeneic CCR5-D32 HSCT for AML in 2013
Presenter: Björn Jensen 
Date: March 6, 2019

CROI 2019, 4-7 March 2019, Seattle, USA
Oral presentation: Sustained HIV-1 remission following Homozygous CCR5 Delta32 Allogeneic HSCT
Presenter: Ravindra Gupta
Date: March 5, 2019

Pre-CROI Community HIV Cure Workshop, 3 March 2019, Seattle, USA
Presentation: Potential for HIV Cure by Stem Cell Transplantation, the IciStem Perspective
Presenter: Monique Nijhuis
Date: March 3, 2019

Ravindra K. Gupta, Sultan Abdul-Jawad, Laura E. McCoy, Hoi Ping Mok, Dimitra Peppa, Maria Salgado, Javier Martinez-Picado, Monique Nijhuis, Annemarie M. J. Wensing, Helen Lee, Paul Grant, Eleni Nastouli, Jonathan Lambert, Matthew Pace, Fanny Salasc, Christopher Monit, Andrew J. Innes, Luke Muir, Laura Waters, John Frater, Andrew M. L. Lever, Simon G. Edwards, Ian H. Gabriel & Eduardo Olavarria 
Naturevolume 568, pages244–248 (2019)

2019 Miami Winter Symposium, 27-30 January 2019, Miami, USA
Presentation: Hematological stem cell therapy to cure HIV infection: So close, so far
Presenter: Javier Martinez-Picado
Date: January 28th, 2019


2018

HIV DART and Emerging Viruses 2018, 27-29 November 2018, Miami, USA
Presentation: Potential for HIV cure by stem cell transplantation (IciStem)
Presenter: Monique Nijhuis
Date: November 27th, 2018

Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant
Salgado M, Kwon M, Gálvez C, Badiola J, Nijhuis M, Bandera A, Balsalobre P, Miralles P, Buño I, Martinez-Laperche C, Vilaplana C, Jurado M, Clotet B, Wensing A, Martinez-Picado J, Diez-Martin JL; IciStem Consortium.
Ann Intern Med. 2018 Nov 20;169(10):674-683. doi: 10.7326/M18-0759. Epub 2018 Oct 16

Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant form
Bosman KJ, Wensing AM, Pijning AE, van Snippenberg WJ, van Ham PM, de Jong DM, Hoepelman AI, Nijhuis M
J Int AIDS Soc. 2018 Sep;21(9):e25185. doi: 10.1002/jia2.25185.

IAS AIDS 2018, 23-27 July 2018, Amsterdam, The Netherlands
Presentation: Stem Cell Transplantations: ICISTEM  
Presenter: Monique Nijhuis
Date: July 26th, 2018

IAS AIDS 2018, 23-27 July 2018, Amsterdam, The Netherlands
Presentation: Dominant HIV DNA populations present in different T-cell subsets before stem cell transplantation persist in tissues early after transplantation with CCR5Δ32 stem cells 
Presenter: Annemarie Wensing
Date: July 24th, 2018

National AIDS Conference, 25-27 May 2018, Jozefow, Poland
HIV cure: Utopia or reality?
Presenter: Annemarie Wensing
Date: May 25th, 2018

16th European Meeting on HIV & Hepatitis 2018, 30 May 2018 - 1 June 2018, Rome, Italy
Oral presentation: Dynamics of HIV DNA populations before and after transplantation with CCR5Δ32 stem cells
Presenter: Annemarie Wensing
Date: May 31st, 2018

44th Annual meeting of the EBMT, 18-20 March 2018, Lisbon, Portugal
HIV Status in long-term follow-up after allogeneic stem cell transplantation: "the Granada patients".
Presenter: Jon Badiola
Date: March 20th 2018


2017

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Oral presentation, title: Achievement of full donor chimerism with episodes of alloreactivity contributes to reduce the HIV reservoir after allogeneic stem cell transplantation
Presenter: Maria Salgado
Date: July 23rd 2017

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Poster, title: Allgeneic stem cell transplantation in HIV-1-infected individuals - the IciStem Consortium: the role of lymphocyte populations
Presenter: Johanna Eberhard

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Poster, title: Murine model to predict viral rebound in HIV+ allotransplanted subjects
Presenter: Maria Salgado

Persistance of HIV DNA in tissues early after transplantation with CCR5Δ32 stem cells
K. Bosman, M. Nijhuis, A. Bruns, M. Salgado, G. Hütter, L. Brosens, J. Martinez-Picado, J. Kuball, A. Wensing
Poster presentation at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI), February 13-16, 2017 in Seattle, Washington.

Murine model to predict viral rebound in HIV+ allotransplanted subjects
Maria Salgado, Mi Kwon, Cristina Galvez Celada, Monique Nijhuis, Cristina Vilaplana, Alessandra Bandera, Annemarie Wensing, Jose Luis Diez, Javier Martinez-Picado
Poster presentation at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI), February 13-16, 2017 in Seattle, Washington.

2016

Is allogeneic stem-cell transplant curative for HIV infection? Bruce Jancin. Hematology News, Vol1 no1, 2016.

Viral Reactivations and Associated Outcomes in Immune Reconstitution after Pediatric Hematopoietic Cell Transplantation. Admiraal R, de Koning C, Bierens M, Lindemans C, Wensing AM, Versluis B, Wolfs T, Nierkens S, Boelens JJ. Accepted for publication in Journal of Allergy and Clinical Immunology

Treatment of HIV and acute myeloid leukemia by allogeneic CCR5-d32 blood stem cell transplantation
E. Knops, G. Kobbe, R. Kaiser, N. Luebke, G. Dunay, A.M.J. Wensing, J. Martinez-Picado, M. Nijhuis, J. Fischer, F. Huettig, R. Haas, D. Haeussinger, B. Jensen.
Poster at HIV Glasgow 2016 (Glasgow, UK)

HIV+ patients and HIV eradication - allogeneic transplantation
G. Hütter
Expert Rev Hematol. 2016 Jul;9(7):615-6. doi: 10.1080/17474086.2016.1183478. Epub 2016 May 10.
PMID: 27139903

2015

Allogeneic Stem Cell Transplantation in HIV-1 Infected Individuals
A.M.J. Wensing, J.L. Diez Martin, G. Hutter, J. Kuball, M. Nijhuis, A. Saez-Cirion, V. Rocha, J. Schulze zur Wiesch, J. Martinez-Picado, for the EPISTEM consortium
Poster at the 7th HIV Persistence during Therapy (Miami, USA)

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir
K.J. Bosman, M. Nijhuis, P.M. van Ham, A.M.J. Wensing, K. Vervisch, L. Vandekerckhove, W. De Spiegelaere
Sci Rep. 2015 Sep 9;5:13811. doi: 10.1038/srep13811. 
PMID: 26350506

Sufficient Immunosuppression with Thymoglobulin Is Essential for a Successful Haplo-Myeloid Bridge in Haploidentical-Cord Blood Transplantation
C.A. Lindemans, L.C.J. te Boome, R. Admiraal, E.C. Jol-van der Zijde, A.M.J. Wensing, A.B. Versluijs, M.B. Bierings, J. Kuball, J.J. Boelens 
Biol Blood Marrow Transplant. 2015 Oct;21(10):1839-45. doi: 10.1016/j.bbmt.2015.06.001. Epub 2015 Jun 26.
PMID: 26119367


CCR5 Δ32 homozygous cord blood allogeneic transplantation in a patient with HIV: a case report
R.F. Duarte, M. Salgado, I. Sánchez-Ortega, M. Arnan, C. Canals, E. Domingo-Domenech, A. Fernández-de-Sevilla, E. González-Barca, S. Morón-López, N. Nogues, B. Patiño, M.C. Puertas, B. Clotet, L.D. Petz, S. Querol, J. Martinez-Picado
Lancet HIV. 2015 Jun;2(6):e236-42. doi: 10.1016/S2352-3018(15)00083-1. Epub 2015 May 19. 
PMID: 26423196

Robust regression methods for real-time polymerase chain reaction
W. Trypsteen, J. De Neve, K. Bosman, M. Nijhuis, O. Thas, L. Vandekerckhove, W. De Spiegelaere 
Anal Biochem. 2015 Jul 1;480:34-6. doi: 10.1016/j.ab.2015.04.001. Epub 2015 Apr 8.
PMID: 25862086




The IciStem project is supported by AmfAR Research Consortium on HIV eradication (ARCHE) Research Grant # 109293-59-RGRL


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