International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation


IciStem is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders.


The IciStem consortium is composed of an expert European review panel of hematologists with experience in allogeneic SCT procedures along with infectious disease specialists, virologist and immunologists with expertise in the field of HIV-1 tropism, reservoirs and cure.

We prospectively study allogeneic SCT recipients with HIV-1 infection, collecting complete information on underlying malignancy, chemotherapy, transplant procedure, donor selection, HIV-tropism, cART, and virological and immunological characteristics of a variety of samples before and after the transplant.


IAS Cure Strategy

A new Cure strategy, developed by the International AIDS Society (IAS) was published on July 11th, 2016, in the journal Nature Medicine: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4108.html

Newsletter

If you want to be kept updated on the IciStem project, you can subscribe to the newsletter here.

NEWS

UMC Utrecht 4th HIV Cure Symposium

On Monday November 20th, 2017 the Translational Virology research group of the Department of Medical Microbiology in the UMC Utrecht will organize the fourth edition of the Utrecht HIV Cure symposium. The focus of this year’s symposium will be on the recent developments and challenges towards HIV cure. This year HIV persistence in reservoirs, latency reversing agents and potential cure via allogenic stem cell transplantation.
Following the link for the program and registration form.

Recent presentations

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Oral presentation, title: Acheivement of full donor chimerism with episodes of alloreactivity contributes to reduce the HIV reservoir after allogeneic stem cell transplantation
Presentor: Maria Salgado
Date: July 23rd 2017

Picture: IAS-ANRS Dominique Dormant Prize: L-R Françoise Barré-Sinoussi, Maria Salgado (winner), François Dabis & Linda-Gail Bekker
9th IAS Conference on HIV Science (IAS 2017) Paris, France. Copyright: Marcus Rose/IAS

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Poster, title: Murine model to predict viral rebound in HIV+ allotransplanted subjects
Presentor: Maria Salgado

IAS HIV Cure & Cancer Forum, 22 & 23 July 2017, Paris, France
Poster, title: Allgeneic stem cell transplantation in HIV-1-infected individuals - the IciStem Consortium: the role of lymphocyte populations
Presentor: Johanna Eberhard

9th IAS Conference on HIV Science, 23-26 July 2017, Paris, France
Poster, title: Allogeneic stem cell transplantation on HIV-1-infected individuals - the IciStem Consortium: the role of lymphocyte populations
Presentor: Maria Salgado

15th EU Meeting on HIV & Hepatitis, 7 - 9 June 2017, Rome, Italy
Oral presentation, title: HIV cure strategies
Presenter: Monique Nijhuis
Date: June 9th 2017
Session: 7

ECCMID, 22 - 25 April 2017, Vienna, Austria 
Oral presentation, title: Potential for HIV cure by stem cell transplantation; the IciStem project
Session Title: Cure for viral diseases
Presenter: Annemarie Wensing
Date: Arpil 23rd 2017
Session Time: 09:00 - 11:00
Session Hall: Hall A

Seminar "Reservorios e investigación básica sobre la curación del VIH", 27 April 2017, Barcelona, Spain
Oral presentation, title: Cell and Gene Therapy in HIV cure strategies
Presenter: Monique Nijhuis





The IciStem project is supported by AmfAR Research Consortium on HIV eradication (ARCHE) Research Grant # 109293-59-RGRL


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